Dysregulation of elastin expression by fibroblasts in pulmonary emphysema : Role of Cellular Retinoic Acid Binding Protein 2 AUTHORS
نویسندگان
چکیده
1: INSERM U700, Hôpital Bichat, Paris, France, 2 : Services de Pneumologie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France, 3 : Université Paris 7, UFR médicale Denis Diderot, Faculté Bichat, Paris, France, 4 : Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France, 5 : Service de Biochimie A, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France, 6 : Service de Physiologie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France, 7 : Service de Chirurgie Thoracique et Vasculaire, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France, 8 : CIC 07, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France.
منابع مشابه
Dysregulation of elastin expression by fibroblasts in pulmonary emphysema: role of cellular retinoic acid binding protein 2.
BACKGROUND All-trans retinoic acid (ATRA) stimulates elastin synthesis by lung fibroblasts and induces alveolar regeneration in animal models of pulmonary emphysema. However, ATRA treatment has had disappointing results in human emphysema. It was hypothesised that a defect in the ATRA signalling pathway contributes to the defect of alveolar repair in the human emphysematous lung. METHODS Fibr...
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